Supportive Care in Cancer. If problems arise with an infusion site the patient may have localised discomfort, or there may be reduced absorption of the medicine and a loss of symptom control. Initially, quizzes are posted out with journals and GPs are invited to submit their answers for CME credits. Search terms were developed in relation to the aims, and MeSH headings were used where available. Fifteen studies reported using sodium chloride 0.

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Table 2 Inclusion and exclusion criteria for systematic search.

This left 21 papers which reported chemical stability and compatibility data for multiple-drug containing syringes over a hour or greater time period Fig 1. In the United Kingdom, the National Institute for Health and Clinical Excellence recommends that the parenteral opioid with the lowest acquisition cost should be used first-line[ 39 ]; for the UK this is currently morphine sulphate.

Barcia et al[ 19 ] investigated the chemical stability and physical compatibility of haloperidol Relevance of data for clinical practice in the UK Of the twenty-four drugs used by the hqloperidol included in the review, twelve are regularly utilised in the prescribing of CSCIs in the United Kingdom cyclizine, dexamethasone, diamorphine, fentanyl, glycopyrrolate, haloperidol, hyoscine hydrobromide, hyoscine- N- butylbromide, metoclopramide, midazolam, morphine sulphate and octreotide [ 37 ].

Minimising reactions at the site of insertion A number of factors influence the longevity of the insertion site.


Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care.

The administration of drugs by subcutaneous infusion is routinely practiced in palliative medicine for the management of patients who are no longer able to take oral medication. Indicate the prescription is for a syringe driver.

BPJ When and how to use a syringe driver in palliative care

More stability data is required before the use of hour CSCIs can be evaluated for use within clinical practice. Evaluation ahd terminal oncology patients. Donnelly; ; Canada [ 21 ]. Supporting information S1 Table Summary of included articles. This can be a concern for patients and families if the clinicians or nurses visit is delayed.

No other clinically significant degradation of drugs was observed at either temperature throughout the period of investigation. However, precipitate formed upon the mixing of ketorolac and methadone dissolved upon being diluted to volume with sodium chloride 0. In the United Mlrphine, current practice for the administration of drugs by CSCI is to limit infusion time to a maximum of hours, as a result of the limited availability of chemical and microbial safety data.

Observational study design—physical stability only confirmed by observing for precipitation. J Pain Symptom Manage. Grassby et al; ; UK [ 17 ].

Twenty-one empirical studies were included in this review. A total of 24 drugs were included in the 21 studies, involving 32 different combinations.

One study employed no form of statistical analysis[ 33 ]. There is currently limited evidence for the physical, chemical and microbiological stability of solutions for continuous subcutaneous infusion over a period of 48 hours. Ensom et al; ; Canada [ 34 ]. Login to my bpac.


The majority of combinations reported were assessed as being chemically compatible. A number of factors influence the longevity of the insertion site.

This left 25 articles in total for full-text assessment, which resulted in a further 4 articles being excluded for not meeting eligibility criteria. Compatibility and stability of tramadol and dexamethasone in solution and its use in terminally ill patients.

When and how to use a syringe driver in palliative care

However, the administration device and syringe in situ may still need to be checked e. A continuous subcutaneous infusion CSCI is an effective method of multiple drug administration haloperirol encountered in end of life care when the oral route is compromised. Register or Log in to take part in quizzes.

As a general guide, plastic cannulae can stay in place for up to a week or more, whereas metal cannulae remain viable for approximately 72 hours.

Journal of Pharmacy and Pharmacology.